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Case Study

Comparative Effectiveness of Ambulatory Monitors for Arrhythmia Diagnosis

New real-world evidence.

The Cardiac Ambulatory Monitor EvaLuation of Outcomes and Time to Events (CAMELOT) study is the first of and largest of its kind and found that Zio long-term continuous monitoring (LTCM) service was associated with the highest diagnostic yield and lowest likelihood of retesting.1-5

Patient wearing Zio AT monitor

Compared to Holter, Ambulatory Event Monitoring (AEM) and Mobile Cardiac Telemetry (MCT) monitoring services, LTCM services as a category had the lowest incremental acute care utilization.1-4

Compared with all other monitoring services, Zio LTCM service was associated with:

Monitor study overview
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Study design and methodology


The claims represent the coding that providers used to document the care they provided to their patients and the follow-up paths those same patients followed. The only claims included in the analysis were for patients who had not had previous cardiac monitoring, resulting in a balanced and comprehensive comparison of retest and healthcare resource utilization.

The first and largest retrospective claims analysis using Medicare fee-for-service documentation.1,5

The cohort included 287,789 patients.

Study chart

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  1. Reynolds et al. Comparative effectiveness and healthcare utilization for ambulatory cardiac monitoring strategies in Medicare beneficiaries. Am Heart J. 2024;269:25–34. Accessed January 2, 2024. https://doi.org/10.1016/j.ahj.2023.12.002
  2. In testing for specified arrhythmias defined by Hierarchical Condition Categories (HCC) 96.
  3. Based on previous generation Zio XT device data. Zio monitor utilizes the same operating principles and ECG algorithm. Additional data on file.
  4. Zio LTCM service refers to Zio XT and Zio monitor service.
  5. Data on file. iRhythm Technologies, 2023.

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